The emphasis of the Systemic Pathology course shifts from the fundamental mechanisms of cell, tissue structural/functional changes and major disease processes to specific examples of the major diseases, which affect each of the vital tissue and organ systems. Particulars of cause and effect, including genetic, molecular, metabolic, infectious, immunologic, nutritional and environmental factors are discussed in conjunction with pathophysiologic manifestations, the typical course or progression of each disease, and the potential for complications